Browsing by Author "Aguirre, Adam"

Now showing items 1-7 of 7

    • A new smoothened antagonist bearing the purine scaffold shows antitumour activity in vitro and in vivo 
      Zarate, Ana María; Espinosa Bustos, Christian; Guerrero, Simón; Fierro, Angélica; Oyarzún Ampuero, Felipe; Geoffery Quest, Andrew; Di Marcotullio, Lucía; Loricchio, Elena; Caimano, Miriam; Calcaterra, Andrea; González Quiroz, Matías; Aguirre, Adam; Meléndez, Jaime; Salas, Cristian O. (MDPI, 2021)
      The Smoothened (SMO) receptor is the most druggable target in the Hedgehog (HH) pathway for anticancer compounds. However, SMO antagonists such as vismodegib rapidly develop drug resistance. In this study, new SMO antagonists ...
    • Biomimetic, Mild Chemical Synthesis of CdTe-GSH Quantum Dots with Improved Biocompatibility 
      Pérez Donoso, José; Monrás, Juan P.; Bravo, Denisse; Aguirre, Adam; Quest, Andrew F. G.; Osorio Román, Igor; Aroca, Ricardo F.; Chasteen, Thomas G.; Vásquez, Claudio C. (2012)
      Multiple applications of nanotechnology, especially those involving highly fluorescent nanoparticles (NPs) or quantum dots (QDs) have stimulated the research to develop simple, rapid and environmentally friendly protocols ...
    • Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski 
      Marcelain Cubillos, Katherine; Armisen Yáñez, Ricardo; Aguirre, Adam; Ueki, Nobuhide; Toro, Jessica; Colmenares, Clemencia; Hayman, Michael J. (WILEY-BLACKWELL, 2012-01)
      Ski is a transcriptional regulator that has been considered an oncoprotein given its ability to induce oncogenic transformation in avian model systems. However, studies in mouse and in some human tumor cells have also ...
    • FasL-Triggered Death of Jurkat Cells Requires Caspase 8-Induced, ATP-Dependent Cross-Talk Between Fas and ... 
      Aguirre, Adam; Shoji, Kenji F.; Sáez, Juan C.; Henríquez Luna, Mauricio; Quest, Andrew F. G. (Wiley Periodicals, Inc., 2013)
      Fas ligation via the ligand FasL activates the caspase-8/caspase-3-dependent extrinsic death pathway. In so-called type II cells, an additional mechanism involving tBid-mediated caspase-9 activation is required to efficiently ...
    • Insights into neutralizing antibody responses in individuals exposed to SARS-CoV-2 in Chile 
      Beltrán Pavez, Carolina Alejandra; Riquelme Barrios, Sebastian Andres; Oyarzún Arrau, Aarón; Gaete Argel, Aracelly Janis; González Stegmaier, Roxana; Cereceda Solis, Karina; Aguirre, Adam; Travisany Flores, Dante Felipe; Palma Vejares, Ricardo Fernando; Barriga Pinto, Gonzalo Andrés; Gaggero Brillouet, Aldo Andres; Martínez Valdebenito, Constanza; Le Corre, Nicole; Ferres Garrido, Marcela Viviana; Balcells, María Elvira; Fernández, Jorge; Ramírez, Eugenio; Villarroel, Franz; Valiente Echeverría, Fernando Andrés; Soto Rifo, Ricardo Andrés (American Association for the Advancement of Science, 2021)
      Chile has one of the worst numbers worldwide in terms of SARS-CoV-2 positive cases and COVID-19-related deaths per million inhabitants; thus, characterization of neutralizing antibody (NAb) responses in the general population ...
    • Phosphorylation of caveolin-1 on tyrosine-14 induced by ROS enhances palmitate-induced death of beta-pancreatic ... 
      Wehinger, Sergio; Ortiz, Rina; Díaz, María Inés; Aguirre, Adam; Valenzuela, Manuel; Llanos Vidal, Paola; Mc Master, Christopher; Leyton Campos, Lisette; Quest, Andrew F. G. (Elsevier, 2015)
      A considerable body of evidence exists implicating high levels of free saturated fatty acids in beta pancreatic cell death, although the molecular mechanisms and the signaling pathways involved have not been clearly ...
    • Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific ... 
      Escobar Álvarez, Alejandro; Aguirre, Adam; Guzmán Meléndez, María Antonieta; González González, Rodrigo; Catalán Martina, Diego; Acuña Castillo, Claudio; Larrondo Lillo, Milton; López Nitsche, Mercedes; Pesce Reyes, Bárbara; Rolland, Jennifer; O’Hehir, Robyn; Aguillón Gutiérrez, Juan Carlos (2014)
      Natural rubber latex (NRL; Hevea brasiliensis) allergy is an IgE-mediated reaction to latex proteins. When latex glove exposure is the main sensitizing agent, Hev b 5 is one of the major allergens. Dendritic cells (DC), ...